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1996-03-09
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Document 0342
DOCN M9650342
TI Temporal trends of initial CD4 cell counts following human
immunodeficiency virus seroconversion in Italy, 1985-1992. The Human
Immunodeficiency Virus Italian Seroconversion Study.
DT 9605
AU Galai N; Lepri AC; Vlahov D; Pezzotti P; Sinicco A; Rezza G; Department
of Epidemiology, School of Hygiene and Public Health,; Johns Hopkins
University, Baltimore, MD, USA.
SO Am J Epidemiol. 1996 Feb 1;143(3):278-82. Unique Identifier : AIDSLINE
MED/96148853
AB To determine whether initial CD4 cell counts after human
immunodeficiency virus (HIV) seroconversion have decreased over calendar
time among participants in the Italian Seroconversion Study, HIV
seroconverters who between 1985 and 1992 had a documented negative
serology followed by a positive serology within 12 months and a first
CD4 cell measurement within 24 months of seroconversion (defined as
midpoint of negative and positive HIV tests) were cross-tabulated by
year of seroconversion. Linear regression methods were used to examine
temporal trends in initial CD4 level after adjustment for age, lag time
of seroconversion, lag time of CD4 cell measurement, risk group, and
clinical center. Between 1985 and 1992, the overall median initial CD4
cell level after seroconversion was 660 microliters with a median lag
time of 212 days and 137 days for seroconversion and first CD4 cell
measurement, respectively. In univariate and multivariate models, the
CD4 cell count increases of 4.3 and 4.2 cells microliters/year,
respectively, were not statistically significant. These data do not
identify a trend of lower CD4 counts following HIV seroconversion in
Italy and suggest indirectly that HIV has probably not become more
virulent between 1985 and 1992.
DE Adolescence Adult Cohort Studies CD4 Lymphocyte Count CD4-Positive
T-Lymphocytes/*IMMUNOLOGY Female Human HIV Antibodies/ANALYSIS HIV
Infections/EPIDEMIOLOGY/*IMMUNOLOGY HIV
Seropositivity/EPIDEMIOLOGY/*IMMUNOLOGY HIV-1/*IMMUNOLOGY
Italy/EPIDEMIOLOGY Linear Models Male Middle Age JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).